Isotretinoin (13-cis-retinoic acid) — oral retinoid
100 film-coated tablets × 20 mg

• Mechanism: shrinks sebaceous glands, cuts sebum up to 80 %, and normalises keratinisation.
• Research applications: severe nodular acne, rosacea, oily-skin reduction, sebaceous hyperplasia.
• Standard research course: 0.5 – 1 mg / kg · day for 15 – 20 weeks; cumulative 120-150 mg / kg.
• Key cautions: teratogenic — strict pregnancy prevention; monitor lipids & liver enzymes.
• QC: ≥ 99 % API purity (HPLC); GMP tablet press; tamper-evident box with scratch-code authenticity.